Steroid sulfatase inhibitors promising new therapy for breast cancer

As a mitochondrial P450 system, P450c11 is dependent on two electron transfer proteins, adrenodoxin reductase and adrenodoxin that transfer 2 electrons from NADPH to the P450 for each monooxygenase reaction catalyzed by the enzyme. In most respects this process of electron transfer appears similar to that of P450scc system that catalyzes cholesterol side chain cleavage. [9] Similar to P450scc the process of electrons transfer is leaky leading to superoxide production. The rate of electron leakage during metabolism depends on the functional groups of the steroid substrate. [10]

This database was created by Callan Corcoran, Cameron Grady, Jaya Parulekar, Trairak Pisitkun, and Mark Knepper in the Epithelial Systems Biology Laboratory ( ESBL ) of the National Heart, Lung, and Blood Institute ( NHLBI ). Please report any additions or corrections to the Knepper Lab via knep@ . If you use this database in any published work, please cite the associated article as follows: Corcoran CC, Grady CR, Parulekar J, Pisitkun T, Knepper MA. From 20th century metabolic wall charts to 21st century systems biology: database of mammalian metabolic enzymes. Am J Physiol Renal Physiol. 2017 Mar 1;312(3):F533-F542. PMID: 27974320 .

Steroid sulfatase inhibitors promising new therapy for breast cancer

steroid sulfatase inhibitors promising new therapy for breast cancer

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