In 2004, Armstrong finished first, 6 minutes 19 seconds ahead of German Andreas Klöden . Ullrich was fourth, a further 2 minutes 31 seconds behind. Armstrong won a personal-best five individual stages, plus the team time trial. He became the first biker since Gino Bartali in 1948 to win three consecutive mountain stages; 15, 16, and 17. The individual time trial on stage 16 up Alpe d'Huez was won in style by Armstrong as he passed Ivan Basso on the way despite having set out two minutes after the Italian. He won sprint finishes from Basso in stages 13 and 15 and made up a significant gap in the last 250 m to nip Klöden at the line in stage 17. He won the final individual time trial, stage 19, to complete his personal record of stage wins. 
Like juice, taking a dose isn’t gonna kill u and I think that’s where we draw a line sometimes by saying they can’t kill u as in a dose can’t harm u !
But over time what it can do is complicate parts of the body and the way your kidneys and heart will function, clogged arteries, high blood pressure ect
So i think there are direct links for sure over time !
But even if there were none !! It could be healthier on the heart to be 250-300 pounds of fat then muscle because of the amount of blood the heart has to pump into the muscle is very taxing on it !!