And, exacerbating these two age-related erosive events, some catabolites
of tryptophan can lead to the formation of mutagenic nitrosamines or
the activation of an immunosuppressive receptor (which is usually
triggered by toxicants such as xenobiotics), promoting carcinogenesis
(Mezrich, et al., 2010; Chung & Gadupudi, 2011).
The consumption of a supplement of tryptophan will likely nurture or augment these disastrous age-associated disease states, by raising injurious tryptophan derivatives (particularly in the presence of a vitamin B6 deficiency, an insufficiency of stomach acid, a magnesium deficit, and a vitamin B3 deficiency).
Furthermore, tryptophan side effects in regards to greater mortality were shown in animal experiments (., Catrina, et al., 2001) using melatonin, whereas the study authors cautioned:
“[...] melatonin had a deleterious effect on the survival rate raising the question whether it is correct to assume that the hormone shows lack of adverse reactions.” [emphasis added]
In regard to serotonin's involvement in the promotion of higher mortality, one of its anti-longevity effects is conceivably the reabsorption of phosphate (a pro-inflammatory chemical) by the kidneys since klotho, an anti-aging protein, facilitates the excretion of phosphate from the kidneys (Peat, Nov. 2012).
Since tryptophan, serotonin, and melatonin meddle with basic energy production in cells, and since metabolic efficiency and functionality decreases proportionally with aging (Fannin, et al., 1999; O'Toole, et al., 2010) due to various factors, it seems coherent in biological terms that these substances are less prevalent, thus less “essential” or needed, in older people, as a further decrease of an already suboptimal general metabolic working order will aggravate physiological function systematically, increase the risk for disease (as exemplified and foreshadowed with tryptophan side effects), promote the aging process, and explains the increased mortality related to the administration of these substances.
Several tryptophan side effects, such as tryptophan's carcinogenic activities, the deterioration of metabolic energy function, and the promotion of hypertension, can rather readily account for a greater death rate.
Thank you Dr. Lynch, This discussion is very helpful about when to back off, and how to prepare the body to respond the best before adding methylfolate. My son could not tolerate much methylfolate to begin with, so we backed off, added some of your optimal turmeric and optimal start for about 3 weeks, and then proceeded to start with the methylfolate and add slowly from there. He is on about to 3mgs currently. We would love to able to recommend to him a multivitamin, but I am concerned about giving him your multi because it combines niacin and methylfolate. Doesn’t that pose a problem together? Won’t the niacin cancel out the methylfolate in the vitamin as well as the excess methylfolate he already takes? What are your thoughts about this, and can you recommend what to do? Obviously, our son is getting niacin in his diet already, as well, but he really needs a multi. Thanks
Hello. I’m curious what you mean that you still suffer from the clot you had years ago. It didn’t dissolve with the Nattokinase and Serrapeptace? Do you suffer from the medicine they had you on? This concerns me because I’m trying to decide if I should take the xarelto my doctor prescribed for the small clot I got from a vein surgery I recently had or if I should stay on the Nattokinase and Serrapeptace I started two days ago. I felt nauseous and scared this morning because my dr told me I’ll be fine as long as I take xarelto. I also might have taken too much. 3times yesterday and also Vit. E, fish oil and aspirin. I might have overdone it. Your opinion would be appreciated.