Mechanism of cardiotonic steroids

The major side effect of digitalis compounds is cardiac arrhythmia, especially atrial tachycardias and atrioventricular block. Digitalis compounds are contraindicated in patients who are hypokalemic, or who have atrioventricular block or Wolff-Parkinson-White (WPW) syndrome. Impaired renal function leads to enhanced plasma levels of digoxin because digoxin is eliminated by the kidneys. Lean, elderly patients are more susceptible to digitalis toxicity because they often have reduced renal function, and their reduced muscle mass increases plasma digoxin levels at a given dose because muscle Na + /K + -ATPase acts as a large binding reservoir for digitalis. A 2012 analysis of the AFFIRM trial determined that digoxin significantly increased all-cause mortality in patients with atrial fibrillation. This calls into question the practice of using digoxin for lowering ventricular rate in patients with atrial fibrillation.

Stress and depression have now become common in day-to-day life. It is because there is so much work pressure and other tensions in life that no one can remain away from these two mental states. Apart from this, hectic lifestyle, wrong eating habits, improper meal times, lack of proper rest and sleep, lack of physical activity and impurity of almost all the foods items are also responsible for stress and depression. Even internal body structure, genes and hormonal imbalance in the body may also lead to stress and depression. This in turn has a negative effect on overall body health. In order to ensure good health and freedom from these negative mental states, you need to use some safe and effective formula so that your brain may be freed of all these thoughts and feelings. And Divya Medha Vati is apt in this regard. It is a unique herbal preparation presented by the pharmacy of Swami Ramdev Ji and helps in dealing with stress, tension, depression and similar mental states. It helps in ensuring overall body health.

  • Divya Medha Vati – Best Mind Booster and Memory Enhancer Herbal Tonic $ – $ Select options

Parts utilized
Pulp, fruit, shoots, leaves, seeds.

Uses
Edibility / Nutrition
- One of the commonest vegetables raised in the Philippines.
- Flesh is white and soft, boiled and seasoned or used in stews or with fish.
- Pulp is an ingredient in many confections.
- Fruit is a good source of iron, calcium, phosphorus, and vitamin B.
- In West Tropical Africa, young shoots, leaves, and flower buds used as vegetable.
- Shoots boiled with milk or coconut milk to reduce the unpleasant flavor.
- Young fruits should be consumed within 2 weeks after harvest. Longer storage causes rapid water loss.
- In Japan , long strips of fruit skin are boiled, soaked in soya sauce with a little sugar, and used as sushi ingredient.
Folkloric
- Young shoots and leaves used for enema.
- Pulp used as purgative adjunct; also used for coughs, asthma, and poison antidote.
- Green fruit in syrup used as a pectoral.
- Leaf juice or sugared decoction used as emetic. Also used in jaundice.
- Crushed leaves used for baldness; applied to the head for headaches.
- Seeds also used as anthelmintic.
- Juice of fruit used for stomach acidity, indigestion and ulcers.
- Poultice of seeds used for boils.
- In the Gold Coast young shoots and leaves used for enema.
- Pulp occasionally used as a adjunct to purgatives. Also used in coughs, and as antidote to certain poisons.
- Externally the pulp is applied as a poultice and cooling preparation to the shaved head in cases of delirium and applied to the soles in burning of the feet.
- Seed oil used as emollient application to the head and as a means of relieving headache. Oil also administered internally.
- In Ayurveda , used as general tonic.
- In China , used for diabetes. Seed oil applied to headache. Decoction used in the treatment of anasarca, ascites, and beriberi. ( 50 )
Others
- The dry shell of the fruit used for domestic utensils, bowls, pipes, bottles, horns or musical instruments.
- Half-fruit shell used as a hat.
- In Kenya, the Luo make a large bugle from the bottle gourds, blown during ceremonies and chasing away animals. Also used for smoking cannabis.

Mechanism of cardiotonic steroids

mechanism of cardiotonic steroids

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