Mecanismo accion corticosteroides pdf

On 9 November 2012, Indian drugmaker Ranbaxy Laboratories Ltd. voluntarily recalled 10-, 20- and 40-mg doses of its generic version of atorvastatin in the United States. [61] The lots of atorvastatin, packaged in bottles of 90 and 500 tablets, were recalled due to possible contamination with very small glass particles similar to the size of a grain of sand (less than 1 mm in size). The FDA received no reports of injury from the contamination. [62] Ranbaxy also issued recalls of bottles of 10-milligram tablets in August 2012 and March 2014, due to concerns that the bottles might contain larger, 20-milligram tablets and thus cause potential dosing errors. [63]

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It has been known for almost 50 years that the physiological effects of aldosterone on epithelial tissues promote Na + and water retention, and K + and Mg 2+ loss. However, aldosterone also has important extrarenal actions which are mediated via the activation of mineralocorticoid receptors in the heart, blood vessels and brain. Recent experimental and clinical findings indicate that aldosterone is an independent risk factor for cardiovascular disease. In fact, an elevated plasma aldosterone level is associated with detrimental effects on the cardiovascular system, including endothelial dysfunction, cardiovascular fibrosis, hypertrophy and inflammation, heart failure, sympathetic nervous system activation, stroke, and renal dysfunction. Moreover, aldosterone receptor antagonists have been shown to reduce the risk of progressive target organ damage in patients with hypertension and heart failure. Eplerenone is a new selective aldosterone receptor antagonist that has been recently approved for use in patients with left ventricular systolic dysfunction and clinical evidence of heart failure following acute myocardial infarction. Compared with spironolactone, eplerenone has greater selectivity for aldosterone receptors than for other steroid receptors, and has superior pharmacokinetic properties. This review focuses firstly on the synthesis, release, and mechanism of action of aldosterone and, thereafter, on the mechanism of action, pharmacodynamic and pharmacokinetic properties, and tolerability of eplerenone.

Mecanismo accion corticosteroides pdf

mecanismo accion corticosteroides pdf

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