Corticosteroids for copd

While the use of inhaled LABAs are still recommended in asthma guidelines for the resulting improved symptom control, [22] further concerns have been raised, by a large meta-analysis of the pooled results from 19 trials with 33,826 participants, that salmeterol may increase the small risks of asthma deaths, and this additional risk is not reduced with the additional use of inhaled steroids (., as with the combination product fluticasone/salmeterol ). [23] This seems to occur because although LABAs relieve asthma symptoms, they also promote bronchial inflammation and sensitivity without warning. [24]

COPD is a critical situation faced by people who show symptoms of lung cancer. The more early this condition is diagnosed among the affected people, that better the chances of recovery are. This disease cannot be cured. However, with early detection and nurturing proper care, the life expectancy can be increased. Intake of advanced medication as prescribed by the doctor helps not only to lead a healthy life but also thwarts all the tensions associated with the disease. People who are affected by COPD must be given enough care and affection on a personal basis besides regular supplements of medicine.

Background: The use of inhaled corticosteroids (ICSs) is associated with an increased risk of pneumonia in patients with COPD. However, the risks of other respiratory infections, such as TB and influenza, remain : Through a comprehensive literature search of MEDLINE, EMBASE, CINAHL, Cochrane Library, and from inception to July 2013, we identified randomized controlled trials of ICS therapy lasting at least 6 months. We conducted meta-analyses by the Peto, Mantel-Haenszel, and Bayesian approaches to generate summary estimates comparing ICS with non-ICS treatment on the risk of TB and : Twenty-fi ve trials (22,898 subjects) for TB and 26 trials (23,616 subjects) for influenza were included. Compared with non-ICS treatment, ICS treatment was associated with a significantly higher risk of TB (Peto OR, ; 95% CI, -) but not influenza (Peto OR, ;95% CI, -). Results were similar with each meta-analytic approach. Furthermore, the number needed to harm to cause one additional TB event was lower for patients with COPD treated with ICSs in endemic areas than for those in nonendemic areas (909 vs 1,667, respectively).Conclusions: This study raises safety concerns about the risk of TB and influenza associated with ICS use in patients with COPD, which deserve further investigation.

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