After ingestion, a large part of the testosterone undecanoate together with the lipophilic solvent is absorbed into the small intestine and enters the lymphatic system, thus avoiding the primary passage through the liver. With the absorption of Testosteron Undecanoat is partially reduced with the formation of dihydrotestosterone undecanoate. From the lymphatic system, he enters the plasma. In the plasma and tissues, as a result of the hydrolysis of testosterone undecanoate and ditrotestosterone undecanoate, the natural male sex hormones testosterone and dihydrotestosterone are released.
A single administration of 80-160 mg of Andriol TC leads to a clinically significant increase in the total plasma concentration of testosterone, Cmax is approximately 40 nmol / L and is achieved 4-5 hours after administration. The increased concentration of testosterone is retained, but at least for 8 hours. It is excreted mainly with urine in the form of conjugates (etiocholanolone and androsterone).
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