17-ketosteroid fractionation

In chronic studies (one year or more) of Prazosin hydrochloride in rats and dogs, testicular changes consisting of atrophy and necrosis occurred at 25 mg/kg/day (75 times the usual maximum recommended human dose). No testicular changes were seen in rats or dogs at 10 mg/kg/day (30 times the usual maximum recommended human dose). In view of the testicular changes observed in animals, 105 patients on long term Prazosin hydrochloride therapy were monitored for 17-ketosteroid excretion and no changes indicating a drug effect were observed. In addition, 27 males on Prazosin hydrochloride for up to 51 months did not have changes in sperm morphology suggestive of drug effect.

17-ketosteroid fractionation

17-ketosteroid fractionation

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